Tyrosine-kinase inhibitors (TKIs) have revolutioned the management of iodine-refractory differentiated thyroid cancer (DTC), previously considered as an orphan disease. VEGF pathway is one of the main molecular target of TKIs. We present a preliminary single center study about the possible role of germline VEGF-A and VEGFR-2 SNPs in predicting objective response and clinical outcome in iodinerefractory DTC patients treated with sorafenib.
Preliminary data of VEGF-A and VEGFR-2 polymorphisms as predictive factors of radiological response and clinical outcome in iodine-refractory differentiated thyroid cancer treated with sorafenib / Marotta, Vincenzo; Sciammarella, Concetta; Capasso, Mario; Testori, Alessandro; Pivonello, Claudia; Chiofalo Maria, Grazia; Pivonello, Rosario; Pezzullo, Luciano; Botti, Gerardo; Colao, Annamaria; Faggiano, Antongiulio. - In: ENDOCRINE. - ISSN 1355-008X. - (2016), pp. 539-543. [10.1007/s12020-016-1200-6]
Preliminary data of VEGF-A and VEGFR-2 polymorphisms as predictive factors of radiological response and clinical outcome in iodine-refractory differentiated thyroid cancer treated with sorafenib
Faggiano Antongiulio
2016
Abstract
Tyrosine-kinase inhibitors (TKIs) have revolutioned the management of iodine-refractory differentiated thyroid cancer (DTC), previously considered as an orphan disease. VEGF pathway is one of the main molecular target of TKIs. We present a preliminary single center study about the possible role of germline VEGF-A and VEGFR-2 SNPs in predicting objective response and clinical outcome in iodinerefractory DTC patients treated with sorafenib.| File | Dimensione | Formato | |
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